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Scientists See Brain Aging Before Symptoms Appear
UCLA scientists have used innovative brain-scan technology developed at UCLA, along with patient-specific information on Alzheimer's disease risk, to help diagnose brain aging, often before symptoms appear. Published in the January issue of Archives of General Psychiatry, their study may offer a more accurate method for tracking brain aging.

Physical Activity May Not Be Key To Obesity Epidemic
A recent international study fails to support the common belief that the number of calories burned in physical activity is a key factor in rising rates of obesity. Researchers from Loyola University Health System and other centers compared African American women in metropolitan Chicago with women in rural Nigeria.

Differentiating Between Healthy Cells And Cancer Cells
One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process.

Majority Of Teens Discuss Risky Behaviors On MySpace, Studies Conclude
In a pair of related studies released by Seattle Children's Research Institute and published in the January 2009 issue of Archives of Pediatric & Adolescent Medicine, researchers found that 54 percent of adolescents frequently discuss high-risk activities including sexual behavior, substance abuse or violence using MySpace, the popular social networking Web site (SNS).

Number Of Babies Exposed To Drugs Effectively Reduced By 'Recovery Coaches'
About 11 percent of the 4 million babies born in the U.S. each year have been exposed to alcohol or illicit drugs in the womb, according to a June 2006 report by the National Center on Substance Abuse and Child Welfare. If removed from the home by child protection, these children tend to remain in foster care longer, and chances are very low that they will be reunited with their parents.

New Tumor Suppressor For Lung Cancer Identified By Cell Biologists
Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biology.

Stanford/UCSF Study Shows That Testes Stem Cell Can Change Into Other Body Tissues
Scientists at the Stanford University School of Medicine and at UC-San Francisco have succeeded in isolating stem cells from human testes. The cells bear a striking resemblance to embryonic stem cells - they can differentiate into each of the three main types of tissues of the body - but the researchers caution against viewing them as one and the same.

Improved Understanding Of Complex Mechanisms That Regulate DNA Damage Control And Replication In The Cell Cycle
Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair.

"On Switch" For Cell Death Signaling Mechanism Discovered By Burnham Researchers
Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell death). The research, performed by Stefan Riedl, Ph.D., and colleagues, published online on Dec.

CSH Protocols Features Methods For Studying DNA Repair And Protein Modification
This month's issue of Cold Spring Harbor Protocols (http://www.cshprotocols.org/TOCs/toc1_09.dtl) features two articles detailing experimental methods for the analysis of molecular processes involved in DNA repair and post-translational modification of proteins. Homologous recombination is an important mechanism for the repair of damaged chromosomes.

Why Smokers Struggle To Quit
Just seeing someone smoke can trigger smokers to abandon their nascent efforts to kick the habit, according to new research conducted at Duke University Medical Center. Brain scans taken during normal smoking activity and 24 hours after quitting show there is a marked increase in a particular kind of brain activity when quitters see photographs of people smoking.

Controlling Type 2 Diabetes With Low-Carb Diets
In a six-month comparison of low-carb diets, one that encourages eating carbohydrates with the lowest-possible rating on the glycemic index leads to greater improvement in blood sugar control, according to Duke University Medical Center researchers.

Treatment Of Patients With Heart Blockage Guided By New Appropriate Use Criteria
If you're committed to fitness, the decision to climb a couple of flights of stairs rather than take the elevator is clear. But if you develop chest pain on the way up, deciding how to treat the symptoms of clogged arteries in your heart is much more complicated.

New Insight Into Effectiveness Of Procedure To Stop Heavy Menstrual Bleeding
Experts estimate that 20 percent of women experience excessive or prolonged menstrual bleeding at some time during their lives, particularly as they approach menopause. A new, less invasive procedure called global endometrial ablation (GEA) preserves the uterus, while decreasing menstrual bleeding and shortening patients' recovery time.

Using Chronic Care Model Helps To Improve People's Health And Care
Ed Wagner, MD, MPH, knew there had to be a better way. He and Group Health colleagues set out 15 years ago to explore how best to engage patients with chronic diseases in effective care. With Robert Wood Johnson Foundation support, they developed the Chronic Care Model. More than 1,500 U.S. and international medical practices have adopted the Model.

Research Grants Must Support Indigenous Researchers, Australia
It is crucial that the National Health and Medical Research Council (NHMRC) continues to develop and fund scholarship programs that support health researchers from Indigenous backgrounds, according to an article in the latest Medical Journal of Australia.

Discovery Of 'Relocation' Plan Of Metastatic Cancer Cells
Few things are as tiresome as house hunting and moving. Unfortunately, metastatic cancer cells have the relocation process down pat. Tripping nimbly from one abode to another, these migrating cancer cells often prove far more deadly than the original tumor.

Genetic Variation May Lead To Early Cardiovascular Disease
Researchers from Duke University Medical Center have identified a variation in a particular gene that increases susceptibility to early coronary artery disease. For years, scientists have known that the devastating, early-onset form of the disease was inherited, but they knew little about the gene(s) responsible until now.

Lifelong Gender Difference In Physical Activity Revealed By Studies
Females of all ages are less active than their male peers. Two studies, presented today (Tuesday 6 January) at a major academic conference, reveal the gender difference in activity levels among school children and the over 70s. Both studies show males to be more physically active than females.

Our Antibodies Take 'Evolutionary Leaps' To Fight Microbes
With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough. A new report in the January 2009 issue of The FASEB Journal (http://www.fasebj.org), explains for the first time how humans keep up with microbes by rearranging the genes that make antibodies to foreign invaders.

GTx Submits NDA For Toremifene 80 Mg For Prevention Of Bone Fractures In Men With Prostate Cancer On Androgen Deprivation Therapy
GTx, Inc. (Nasdaq: GTXI) announced the submission of a New Drug Application with the U.S. Food and Drug Administration (FDA) for toremifene 80 mg, an oral selective estrogen receptor modulator (SERM), for the prevention of bone fractures in men with prostate cancer on androgen deprivation therapy (ADT). "ADT has helped improve survival for men with advanced prostate cancer.

Discovery Of Uncultured Bacteria In Amniotic Fluids Of Women Who Experience Preterm Births
Researchers from Case Western Reserve University and Yale University have made a significant advancement in understanding the cause behind why some pregnant women suffer from inflammations in the inner womb without any signs of an infection.

New Device Couples, Fuses Cells For Stem Cell Research
MIT engineers have developed a new, highly efficient way to pair up cells so they can be fused together into a hybrid cell. The new technique should make it much easier for scientists to study what happens when two cells are combined. For example, fusing an adult cell and an embryonic stem cell allows researchers to study the genetic reprogramming that occurs in such hybrids.

UM Genetic Researchers Release New Findings On Alzheimer's Disease
Researchers at the University of Miami Miller School of Medicine led by Margaret A. Pericak-Vance, Ph.D., and Jonathan L. Haines, Ph.D. at Vanderbilt University Medical Center, have identified nine genes that may increase susceptibility for Alzheimer's disease and confirmed a region on chromosome 12q long believed to harbor an Alzheimer's risk gene.

Kidneys For Transplant Function Earlier And Last Longer When Preserved In A Machine Compared To The Traditional Box Of Ice
Results from a landmark trial published in the New England Journal of Medicine, show that in transplanted kidneys preserved and transported in a specially designed machine (LifePort Kidney Transporter) the odds for experiencing a delay in recovery of kidney function are 43% lower, and tha

Offspring Benefit From Disease Clues During Pregnancy
When there is a threat of disease during pregnancy, mothers produce less aggressive sons with more efficient immune systems, researchers at The University of Nottingham have discovered.

UQ Scientists Closing The Zap On Dengue Fever
A mosquito-borne virus that each year harms up to 100 million people and kills more than 20,000 is a step closer to being controlled after a breakthrough by Queensland scientists.

Early Childhood Monitoring Imperative, Canada
Universal, affordable access to early childhood programs is essential to help young children develop their potential. Equally important are measurement systems to help determine what supports are needed for children. The components of a high quality measurement system exist in Canada but need to be coordinated and applied consistently across the country, write Dr.

Obesity Starts Earlier Than You Think
Recent reports have indicated that childhood obesity is set in place by the age of five, but, "Actually, it starts in the womb," says Dr. Barry Sears, one of the world's leading experts on the impact of diet on hormones and gene expression. "Obesity has an exceptionally strong genetic component.

Comprehensive Study Of Medicaid Records Finds Substance Abuse Increases The Cost Of Other Health Problems
People with substance abuse disorders cost Medicaid hundreds of millions of dollars annually in medical care, suggesting that early interventions for substance abuse could not only improve outcomes but also save substantial amounts of money, according to a comprehensive study that examined records of nearly 150,000 people in six states.

PHR Criticizes Iran For Trying AIDS Doctors On Secret Charges
The Iranian government's December 31 trial of Dr. Arash Alaei and Dr.

Unicompartmental As Good Total Knee Replacement At 15 Years
A study published in The Journal of Bone and Joint Surgery, British Volume has summarised the results from a 15 year follow-up of a randomised trial that took place between 1989 and 1992 whereby 102 knees we given either a unicompartmental knee replacement (UKR) or a total knee replacement (TKR).

Exertion At Work And Play Can Trigger Deadly Asthma Attacks
If you're an asthma sufferer, make sure the medical history at your doctor's office includes your employment and recreation plans. A new screening tool developed by Tel Aviv University researchers may save you a trip to the emergency room later on.

Susan Lark, MD Urges Women To Fight For Their Right To Use Bioidentical Hormones
Susan Lark, MD, noted medical researcher and women's health practitioner, is urging women to continue waging a battle against the Food and Drug Administration's (FDA) steps to limit their access to bioidentical hormones.

UPMC Sports Medicine Invites Sedentary, Over-40 Adults To Enroll In 'Start' Fitness Program
Experts from the UPMC Center for Sports Medicine urge over-40 men and women to enroll in Start, a lifestyle-changing fitness program that will help participants realistically incorporate exercise into their presently inactive lifestyles. Beginning Jan.

New Genetic Markers For Ulcerative Colitis Identified, Researchers Report In Nature Genetics
An international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature GeneticsUniversity of Pittsburgh Medical Center U.S. Steel Tower 600 Grant St., 57th Floor, Pittsburgh, PA 15213 United States http://www.upmc.

Addressing Substance Abuse And Comorbidities Among Military Personnel, Veterans, And Their Families: A Research Agenda
There is growing concern that military personnel returning from Iraq and Afghanistan are experiencing a range of difficulties, including traumatic brain injury (TBI), post traumatic stress disorder (PTSD), depression, anxiety, and tobacco, alcohol and drug abuse.

News From The Journal Of The American Society Of Plastic Surgeons, January 2009
Can The US Really Cut Health Care Spending? A new study suggests that while health care is one of the strongest sectors of the ailing US economy, achieving a substantial, sustainable reduction is US health care spending is not probable.

Treating Femoral Fractures With Limited Resources
An article published in The Journal of Bone and Joint Surgery, British Volume demonstrates that in cases where resources are limited and there is a delay from injury to treatment, femoral fractures can heal successfully without stabilisation by external or internal fixation.

Possible Mechanism Of Muscle Denervation In Emery-Dreifuss Muscular Dystrophy
Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. MÃ©jat et al. show that one mechanism involves the disruption of neuromuscular junctions. The study appeared online on Monday, January 5, 2009 (http://www.jcb.

Interpreter Association IMIA Starts Campaign To Promote Code Of Ethics For Medical Interpreters Worldwide
The International Medical Interpreters Association, IMIA, announced its intention to disseminate the IMIA Code of Ethics worldwide, and to that end the first code of ethics for medical interpreters has now been translated into eleven languages: Arabic, Chinese (Traditional and Sim

Mental Functioning Slowed By Adult-Onset Diabetes With Deficits Appearing Early
Adults with diabetes experience a slowdown in several types of mental processing, which appears early in the disease and persists into old age, according to new research. Given the sharp rise in new cases of diabetes, this finding means that more adults may soon be living with mild but lasting deficits in their thought processes.

Time To Quit Smoking, Says BUPA, UK
Keeping the toughest New Year's resolution of them all could be made a little easier for Facebook users this year thanks to a new application - the Bupa 'QuitClock'. Bupa has exclusively designed this new application to both help and encourage any potential ex-smoker to give up cigarettes.

Childhood Trauma And Risk For Chronic Fatigue Syndrome Connected By Biological Link
Childhood trauma is a potent risk factor for development of chronic fatigue syndrome (CFS), according to a study by researchers at Emory University School of Medicine and the Centers for Disease Control and Prevention (CDC). The study is published in the Jan. 5, 2009Archives of General Psychiatry.

Treadmill Desks More Effective In Cancer Prevention For Women Than Vitamin C, E And Beta Carotene Supplementation
Yet another study published online by the Journal of the National Cancer Institute confirmed that vitamin supplementation provided no statistically significant value in cancer prevention among women. This study comes on the heels of numerous studies which all draw the same conclusion: vitamin supplementation among a normally well nourished population has no positive effect on cancer prevention.

FDA Approvals For Sterile Vancomycin HCl USP, 500 Mg/Vial; 1 G/Vial And Sterile Vancomycin HCl USP, 5 G/Vial Pharmacy Bulk Package
Akorn-Strides, LLC announced that the U.S. Food and Drug Administration has granted approvals for two Abbreviated New Drug Applications (ANDAs) for Sterile Vancomycin HCl USP, 500 mg/vial, 1 g/vial and Sterile Vancomycin HCl USP, 5 g/vial Pharmacy Bulk Package. Akorn-Strides, LLC is a Joint Venture that was formed in 2004 by Akorn, Inc.

News From The Annals Of Internal Medicine Jan. 6, 2009
1. Outbreaks of Viral Hepatitis Linked to Lapses in Infection Control Practices in Health Care Settings While transmission of Hepatitis B (HBV) and Hepatitis C (HCV) virus in health care settings is considered rare, recent reports of outbreaks indicate a growing problem. Over the past decade, there have been 33 outbreaks in nonhospital health care settings in the United States.

Potential Kennedy Senate Appointment 'Discouraging' For 'Faithful' Catholic Voters, WSJ Opinion Piece Says
Although the "thought of yet another pro-choice Kennedy positioned to campaign for the unlimited right to abortion is discouraging" for "faithful" Roman Catholics, abortion-rights advocates "will have just such a champion" if Caroline Kennedy is appointed to fill the Senate seat that will be vacated by Sen. Hillary Rodham Clinton (D-N.Y.

Two Teens With Lupus Win Spots In The Rose Parade With Kaiser Permanente
Two southern California teens living with lupus will be among the riders aboard the Kaiser Permanente float in the 120th Annual Tournament of Roses Parade on January 1, 2009. Nathalie Gonzales and Jessica Southern will appear on the float with 12 other riders, ages 12 through 18, who are battling life-threatening diseases, including lupus, cancer, and sickle-cell anemia.

Obesity Comes With A Price Tag
There are hard dollars-and-cents costs to being overweight or obese, according to Humana (NYSE: HUM), one of the nation's largest health benefits companies. Specifically, Humana estimates these costs at the following for 2009: - $19.39 in added health care costs for every overweight pound; - $1,037.64 for every overweight individual; - $127 billion added to the national health care bill.

Molecular Insight Into The Workings Of A Heart Failure Drug In Clinical Trials
Individuals who have persistent high blood pressure are at increased risks of a number of serious medical conditions, including heart failure. One of the factors that contributes to such heart failure is thickening of the muscle wall of the heart. Such thickening (known as hypertrophy) is a compensatory response of the heart to the high blood pressure.

Medical Errors, Apologies And Apology Laws
Editorial Apologizing for medical errors is both ethically and professionally responsible and also crucial for improving patient safety and quality of care, write Dr. Noni MacDonald and Dr. Amir Attaran and the CMJA editorial team. They point out that an apology can have significant healing effects for the patient, family and physician.

Pain Caused By Physical Insult Sensed By Nerve Cells In The Brain And Spinal Cord
The most common way of managing the pain that accompanies inflammation is to use drugs such as aspirin and ibuprofen. These work by selectively blocking the protein COX2, which functions to produce soluble molecules known as prostaglandins.

Military Order Of The Purple Heart Supports New Initiative For Veterans
The Military Order of the Purple Heart (MOPH) issued a strong statement in support of a new Veteran benefit initiative by U.S. Rep. Steve Buyer, Ranking Member of the House Committee on Veteran's Affairs.

Link Between Maternity Leave, Fewer C-Sections And Increased Breastfeeding
Two new studies led by researchers at the University of California, Berkeley, suggest that taking maternity leave before and after the birth of a baby is a good investment in terms of health benefits for both mothers and newborns.

Pneumococcal Vaccine Does Not Appear To Protect Against Pneumonia
Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom.

New Eating Plan Makes Weight Loss Extra Easy
Every January millions of people in the UK make a New Year's resolution to lose weight. Seventy five per cent of adults make weight loss their number one aim, but most have given up by the end of the month. The good news for those seeking to eat more healthily without hunger and deprivation is that it is easy to eat to satisfy your appetite and enjoy an everyday treat too.

In Breast Cancers With Poor Prognosis Gene Plays Dual Role
A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, identifies MTDH as a promising therapeutic target for high risk breast cancers.

Similar Long-term Mortality Risks In Men With Type 2 Diabetes And Men With Cardiovascular Disease
Men with type 2 diabetes and men with previous heart attack or stroke had a 3 to 4 fold risk of cardiovascular death compared to men without either disease in the years following the first acute event, according to a study in CMAJ.

New Insight Into Aggressive Childhood Cancer
A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, may lead to development of future strategies for treatment of this aggressive and unpredictable cancer.

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